| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--uncut; EcoRI--4.9; HindIII--4.9; SalI--4.9; EcoRI/HindIII--3.45, 1.55; HindIII/SalI--3.6, 1.2. Detects loss of heterozygosity in renal cell carcinoma. Enzyme(s) not detecting polymorphism: MboI, TaqI, EcoRI, HindIII, BamHI, BglII, BclI, HincII, PstI, NciI, SstI, XmaI, HaeIII, BstNI, BstEII, AccI, StuI, RsaI, EcoRV, AluI, SinI, DdeI, NaeI. |
| References |
Barker D, et al. Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell 36: 131-138, 1984. PubMed: 6198090
Naylor SL, et al. DNA polymorphic loci mapped to human chromosome 3, 5, 9, 11, 17, 18, and 22. Proc. Natl. Acad. Sci. USA 81: 2447-2451, 1984. PubMed: 6585809
Zbar B, et al. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327: 721-724, 1987. PubMed: 2885753
Kovacs G, et al. Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. Proc. Natl. Acad. Sci. USA 85: 1571-1575, 1988. PubMed: 2894030
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